Estimating the distribution function using k-tuple ranked set samples

The basic assumption underlying the concept of ranked set sampling is that actual measurement of units is expensive, whereas ranking is cheap. This may not be true in reality in certain cases where ranking may be moderately expensive. In such situations, based on total cost considerations, k-tuple ranked set sampling is known to be a viable alternative, where one selects k units (instead of one) from each ranked set. In this article, we consider estimation of the distribution function based on k-tuple ranked set samples when the cost of selecting and ranking units is not ignorable. We investigate estimation both in the balanced and unbalanced data case. Properties of the estimation procedure in the presence of ranking error are also investigated. Results of simulation studies as well as an application to a real data set are presented to illustrate some of the theoretical findings.     

Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation

Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics.     

A decision support system for the selection of a casting process using analytic hierarchy process

This paper presents an Analytic Hierarchy Process (AHP) based decision support system to select the most suitable casting process for a given product. The hierarchical structure of the proposed method allows the decision maker to compare the different casting processes using the material suitability and flexibility, geometrical complexity, dimensional tolerance and surface finish of the casting, and the cost as the criteria for selection. Judgemental inconsistency of the decision maker in selecting the casting process is taken care by ensuring that the value of consistency ratio is below (0.1). A numerical example is presented to illustrate the effectiveness of the proposed methodology for selecting the suitable casting process.     

A nonparametric bayesian approach to analysis of drug dependence data

In this paper, a nonparametric Bayesian approach to the analysis of binary response data is considered. Using a Dirichlet process prior, and squared error loss, the Bayes estimators of response probabilities are obtained. Finally, the results obtained are employed to analyze the ARC 090 Trial data.     

Nonparametric bayes estimation of the survival function from a record of failures and follow-ups

In some observational studies, we have random censoring model. However, the data available may be partially observable censored data consisting of the observed failure times and only those nonfailure times which are subject to follow-up. Suzuki (1985) discussed the problem of nonparametric estimation of the survival function from such partially observable censored data. In this article, we derive a nonparametric Bayes estimator of the survival function for such data of failures and follow-ups under a Dirichlet process prior and squared error loss. The limiting properties such as the mean square consistency, weak convergence and strong consistency of the Bayes estimator are studied. Finally, the procedures developed are illustrated by means of an example.     

Goodness‐of‐fit tests for parametric models based on biased samples

The authors study the problem of checking the adequacy of a parametric model for a distribution using several possibly censored weight biased samples. They discuss identifiability problems related to the underlying distribution and the distributions of the biased samples. They propose a test statistic based on the supremum of the weighted aggregated martingale residual processes from a number of such samples. Both numerical and graphical procedures are discussed, which the authors apply to do model checking for oil exploration drilling data.     

Bayesian model selection for join point regression with application to age-adjusted cancer rates

Summary.  The method of Bayesian model selection for join point regression models is developed. Given a set of K +1 join point models M ₀,  M ₁, …,  M _K with 0, 1, …,  K join points respec-tively, the posterior distributions of the parameters and competing models M _k are computed by Markov chain Monte Carlo simulations. The Bayes information criterion BIC is used to select the model M _k with the smallest value of BIC as the best model. Another approach based on the Bayes factor selects the model M _k with the largest posterior probability as the best model when the prior distribution of M _k is discrete uniform. Both methods are applied to analyse the observed US cancer incidence rates for some selected cancer sites. The graphs of the join point models fitted to the data are produced by using the methods proposed and compared with the method of Kim and co-workers that is based on a series of permutation tests. The analyses show that the Bayes factor is sensitive to the prior specification of the variance σ ², and that the model which is selected by BIC fits the data as well as the model that is selected by the permutation test and has the advantage of producing the posterior distribution for the join points. The Bayesian join point model and model selection method that are presented here will be integrated in the National Cancer Institute's join point software ( http://www.srab.cancer.gov/joinpoint/ ) and will be available to the public.     

Multi-stage estimation of the common location parameter of several exponential distributions

The problem of constructing a confidence interval of ‘preassigned width and coverage probability’ considered by Costanza/ Hamdy and Son(1986) is further analyzed. Several multi-stage estimation procedures [ like, purely sequential, accelerated sequential and three-stage procedures ] are utilized to deal with the same estimation problem. The relative advantages and disadvantages of these procedures are discussed.     

Analyzing time–frequency relationship between oil price and exchange rate in Pakistan through wavelets

This study analyzed the time–frequency relationship between oil price and exchange rate for Pakistan by using measures of continuous wavelet such as wavelet power, cross-wavelet power, and cross-wavelet coherency (WTC). The results of cross-wavelet analysis indicated that covariance between oil price and exchange rate is unable to give clear-cut results, but both variables have been in phase and out phase (i.e. they are anti-cyclical and cyclical in nature) in some or other durations. However, results of squared wavelet coherence disclose that both variables are out of phase and real exchange rate was leading during the entire period studied, corresponding to the 10–15 months’ scale. These results are the unique contribution of the present study, which would have not been drawn if one would have utilized any other time series or frequency domain-based approach. This finding provides evidence of anti-cyclical relationship between oil price and real effective exchange rate; however, in most of the period studied, real exchange rate was leading and passing anti-cycle effects on oil price shocks which is the major contribution of the study.